Invention Grant
- Patent Title: Peptide-based molecules for modulating car expression or accessibility and uses thereof
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Application No.: US15743039Application Date: 2016-07-09
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Publication No.: US10736971B2Publication Date: 2020-08-11
- Inventor: Katherine Julie Diane Ashbourne Excoffon , Priyanka Sharma
- Applicant: Wright State University
- Applicant Address: US OH
- Assignee: WRIGHT STATE UNIVERSITY
- Current Assignee: WRIGHT STATE UNIVERSITY
- Current Assignee Address: US OH
- Agency: McNees Wallace & Nurick LLC
- International Application: PCT/US2016/041671 WO 20160709
- International Announcement: WO2017/008067 WO 20170112
- Main IPC: A61K47/62
- IPC: A61K47/62 ; A61K38/16 ; C07K14/705 ; G01N33/566

Abstract:
Peptide-based molecules for modulating expression or accessibility to the coxsackievirus and adenovirus receptor (CAR) are disclosed. Cell-permeable peptide-based molecules having a PDZ-decoy domain or PDZ-binding domain are used to modulate the expression or accessibility of CAR molecules, thereby affecting the ability of viral molecules, or molecules containing viral sequences or proteins able to bind CAR, to enter host cells.
Public/Granted literature
- US20180311369A1 PEPTIDE-BASED MOLECULES FOR MODULATING CAR EXPRESSION OR ACCESSIBILITY AND USES THEREOF Public/Granted day:2018-11-01
Information query
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