Methods and systems are described herein for fluid handling and dispensing liquid substances using vaporization or nebulization in a controlled, safe manner. A dispensing device may be configured to receive one or more cartridges storing different types of vaporizable or nebulizable substances. A controller may be provided to regulate the amount of a given substance dispensed over a defined time period. Optionally, in response to detecting tampering of the dispensing device and/or a liquid cartridge the dispensing device may be disabled and/or a liquid stored in a substance cartridge may be rendered inert.