A cleaning system is disclosed for cleaning concrete residue from a concrete mixer truck. The cleaning system may include a water delivery system having one or more conduits configured to deliver pressurized water to one or more spray headers positioned at various back-end portions of the truck. The cleaning system further includes one or more valves configured to control the flow of pressurized water through the one or more conduits to the one or more spray headers. In various embodiments, the one or more valves are manually operable to control the release of water to the spray headers. In other embodiments, the one or more valves are controlled by a computing device through an electrical coupling such as a communication bus. The cleaning system may be configured to clean different portions of the truck using different sets of spray headers at different times as part of a washing protocol.