Invention Grant
- Patent Title: Use of a polypeptide for effecting immune signalling and/or affecting intestinal barrier function and/or modulating metabolic status
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Application No.: US15571175Application Date: 2016-05-04
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Publication No.: US10738089B2Publication Date: 2020-08-11
- Inventor: Clara Belzer , Willem Meindert De Vos , Patrice Daniel Cani
- Applicant: WAGENINGEN UNIVERSITEIT , UNIVERSITE CATHOLIQUE DE LOUVAIN
- Applicant Address: NL Wageningen BE Louvain-la-Neuve
- Assignee: WAGENINGEN UNIVERSITEIT,UNIVERSITÉ CATHOLIQUE DE LOUVAIN
- Current Assignee: WAGENINGEN UNIVERSITEIT,UNIVERSITÉ CATHOLIQUE DE LOUVAIN
- Current Assignee Address: NL Wageningen BE Louvain-la-Neuve
- Agency: Lathrop GPM LLP
- Agent James H. Velema, Esq.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@17847c6f
- International Application: PCT/EP2016/060033 WO 20160504
- International Announcement: WO2016/177797 WO 20161110
- Main IPC: A61K39/00
- IPC: A61K39/00 ; C07K14/195 ; C12N1/20 ; A61P3/08 ; A61P3/06 ; A61K38/00
Abstract:
It has been found that an extracellular polypeptide derived from Akkermansia municiphila is capable of modulating and/or promoting gut mucosal immune system function and/or maintaining and/or restoring metabolic status and/or increasing the physical integrity of the gut mucosal barrier in a mammal. The polypeptide or host cells including such polypeptide may be employed to prevent and/or treat a variety of conditions that benefit from an increased physical integrity of the gut mucosal barrier and/or an improved gut mucosal immune system function and metabolic status.
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