Invention Grant
- Patent Title: Dual specific anti-CD22-anti-CD19 chimeric antigen receptors
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Application No.: US15559485Application Date: 2016-03-18
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Publication No.: US10738116B2Publication Date: 2020-08-11
- Inventor: Terry J. Fry , Crystal L. Mackall , Rimas J. Orentas , Waleed Haso , Haiying Qin
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2016/023055 WO 20160318
- International Announcement: WO2016/149578 WO 20160922
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/725 ; C07K14/705 ; A61P35/00 ; G01N33/574
Abstract:
The invention provides dual specific chimeric antigen receptors (CARs) having antigenic specificity for CD19 and CD22. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
Public/Granted literature
- US20180111992A1 DUAL SPECIFIC ANTI-CD22-ANTI-CD19 CHIMERIC ANTIGEN RECEPTORS Public/Granted day:2018-04-26
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