Modifying a motion plan for an autonomously-operated inspection platform (AIP) includes obtaining sensor data for an industrial asset area of interest, analyzing the obtained sensor data during execution of an initial motion plan to determine if modification of the initial motion plan is required. If modification is required then performing a pose estimation on a first group of potential targets and a second group of potential targets, optimizing the results of the pose estimation to determine a modification to the initial motion plan, performing reactive planning to the initial motion plan to include the modification, the reactive planning providing a modified motion plan that includes a series of waypoints defining a modified path, and autonomously controlling motion of the AIP along the modified path. The analysis, pose estimation, optimization, and reactive planning occurring during movement of the AIP along a motion plan. A system and computer-readable medium are disclosed.