A computer-implemented method for manufacturing an integrated circuit chip is disclosed. The method includes selecting cell-based circuit representations to define an initial circuit design. The initial circuit design is partitioned into multiple sub-design blocks to define a partitioned design. Circuit representations of local clock sources are inserted into the partitioned design. Each local clock source is for clocking a respective sub-design block and based on a global clock source. A timing analysis is performed to estimate skew between each local clock source and the global clock source. The partitioned design is automatically modified based on the estimated skew.