The invention relates to method and apparatus for reconstructing a three-dimensional representation of a target volume inside an animal or human body.Hereto, according to the method step ii) is preceded by the steps of: a1) displaying said first two-dimensional image projection being obtained in step i) for a user using said displaying means, a2) acquiring a first operational orientation setting of said imaging means corresponding with said first imaging position; a3) defining based on said first operational orientation setting a first set of second operational orientation settings of said imaging means for orientation in a second imaging position; a4) selecting from said set one of said second operational orientation settings; a5) using said second operational orientation setting being selected for acquiring said second two-dimensional image projection of said target volume using said imaging means being positioned in the second imaging position corresponding to said second operational orientation setting. Accordingly, with these features an improved reconstructing method is obtained, wherein an optimal set of two-dimensional image projections is obtained and proposed, based on which a correct three-dimensional contour image of said target volume is being reconstructed. Thus with this correct three-dimensional contour image the diagnostician is capable of performing a more accurate diagnosis and subsequent treatment of the patient, which in turn is subjected to a less lengthy imaging treatment session, which is beneficial in terms of radiation exposure time, discomfort, etc.