Systems and methods for ultrasonic collision management in virtual, augmented, and mixed reality (xR) applications are described. In some embodiments, an Information Handling System (IHS) may include a processor and a memory coupled to the processor, the memory having program instructions stored thereon that, upon execution by the processor, cause the IHS to: execute an xR application to display an xR image to a user of the IHS; and detect, via an ultrasonic sensor coupled to the processor, a potential physical interaction between the user and a physical object during execution of the xR application.