Provided are a method and an apparatus for measuring inter-RU interference in order to perform space division duplex communication in a wireless communication system. Specifically, a terminal acquires first interference information indicating the strength of inter-RU interference after analog interference cancellation, and second interference information indicating the strength of inter-RU interference before analog interference cancellation. The terminal determines whether space division duplex communication can be performed between RUs, by comparing the interference strength indicated by the first interference information with a first threshold. The terminal determines whether inter-RU interference needs to be periodically measured, by comparing the interference strength indicated by the second interference information with a second threshold.