Invention Grant
- Patent Title: Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies
-
Application No.: US16082219Application Date: 2017-03-09
-
Publication No.: US10745380B2Publication Date: 2020-08-18
- Inventor: Paul Anthony Stupple
- Applicant: CTXT PTY LTD
- Applicant Address: AU Victoria
- Assignee: CTXT PTY LTD
- Current Assignee: CTXT PTY LTD
- Current Assignee Address: AU Victoria
- Agency: Stites & Harbison PLLC
- Agent Richard S. Myers, Jr.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@9c52b7e
- International Application: PCT/EP2017/055538 WO 20170309
- International Announcement: WO2017/153521 WO 20170914
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D213/82 ; A61K31/4545 ; A61K31/455
Abstract:
A compound of formula (Ia), (Ib) or (Ic) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R2c and R2d (if present) are independently selected from the group consisting of: (i) F; (ii) H; (iii) Me; and (iv) CH2OH; R3a and R3b are independently selected from H and Me; R4a is selected from OH, —NH2, —C(═O)NH2, and —CH2OH; R4b is either H or Me; R5 is either H or Me; A is either (i), where R6a is ether; or (ii), where X is selected from CH2, NH and O, one of R7a and R7b is selected from CI and ethoxy and the other of R7a and R7b is H.
Public/Granted literature
- US20200039956A1 PYRIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER AND HEMOGLOBINOPATHIES Public/Granted day:2020-02-06
Information query
