Invention Grant
- Patent Title: Methods and compositions for antibody-evading virus vectors
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Application No.: US15763706Application Date: 2016-09-28
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Publication No.: US10745447B2Publication Date: 2020-08-18
- Inventor: Aravind Asokan , Mavis Agbandje-McKenna , Long Ping Victor Tse , Brittney Gurda
- Applicant: The University of North Carolina at Chapel Hill , University of Florida Research Foundation, Inc.
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel, P.A.
- International Application: PCT/US2016/054143 WO 20160928
- International Announcement: WO2017/058892 WO 20170406
- Main IPC: C07K14/005
- IPC: C07K14/005 ; C07K16/08 ; C12N15/86 ; A61K39/00
Abstract:
The present invention provides AAV capsid proteins comprising a modification in the amino acid sequence and virus vectors comprising the modified AAV capsid protein. The invention also provides methods of administering the virus vectors and virus capsids of the invention to a cell or to a subject in vivo.
Public/Granted literature
- US20190048041A1 METHODS AND COMPOSITIONS FOR ANTIBODY-EVADING VIRUS VECTORS Public/Granted day:2019-02-14
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