- Patent Title: Methods for modulating production profiles of recombinant proteins
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Application No.: US15743709Application Date: 2016-07-07
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Publication No.: US10745663B2Publication Date: 2020-08-18
- Inventor: Anais Muhr , David Bruhlmann , Martin Jordan , Herve Broly , Matthieu Stettler
- Applicant: ARES TRADING S.A.
- Applicant Address: CH Aubonne
- Assignee: ARES TRADING S.A.
- Current Assignee: ARES TRADING S.A.
- Current Assignee Address: CH Aubonne
- Agency: Saliwanchik, LLoyd & Eisenschenk
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@3dc04497
- International Application: PCT/EP2016/066108 WO 20160707
- International Announcement: WO2017/012883 WO 20170126
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C07K16/18 ; C07K16/28
Abstract:
The invention is in the field of cell culture. Particularly the invention relates to methods of culturing a host cell expressing a recombinant protein in a cell culture medium comprising an effective amount of 4,4′diisothiocyanostilbene-2,2′-disulfonic acid (DIDS) or supplemented with an effective amount of DIDS, whereby production of said protein is increased relative to cells grown without DIDS.
Public/Granted literature
- US20180201896A1 METHODS FOR MODULATING PRODUCTION PROFILES OF RECOMBINANT PROTEINS Public/Granted day:2018-07-19
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