Invention Grant
- Patent Title: Heme protein catalysts for carbon-boron bond formation in vitro and in vivo
-
Application No.: US15914788Application Date: 2018-03-07
-
Publication No.: US10745673B2Publication Date: 2020-08-18
- Inventor: S. B. Jennifer Kan , Xiongyi Huang , Kai Chen
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
- Current Assignee Address: US CA Pasadena
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C12P17/12
- IPC: C12P17/12 ; C12P17/10 ; C12N9/02 ; C07K14/195

Abstract:
Provided herein are methods for producing an organoboron product. The methods include combining a boron-containing reagent and a carbene precursor in the presence of a heme protein, e.g., a cytochrome c, a cytochrome P450, a globin, a protoglobin, a nitric oxide dioxygenase, a peroxidase, or a catalase, or a variant thereof, under conditions sufficient to form the organoboron product. Reaction mixtures for producing organoboron products are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming carbon-boron bonds.
Public/Granted literature
- US20180273917A1 HEME PROTEIN CATALYSTS FOR CARBON-BORON BOND FORMATION IN VITRO AND IN VIVO Public/Granted day:2018-09-27
Information query