Invention Grant
- Patent Title: Coupling endonucleases with end-processing enzymes drives high efficiency gene disruption
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Application No.: US15215461Application Date: 2016-07-20
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Publication No.: US10745689B2Publication Date: 2020-08-18
- Inventor: Andrew M. Scharenberg , Michael T. Certo , Kamila Sabina Gwiazda
- Applicant: Seattle Children's Hospital
- Applicant Address: US WA Seattle
- Assignee: SEATTLE CHILDREN'S RESEARCH INSTITUTE
- Current Assignee: SEATTLE CHILDREN'S RESEARCH INSTITUTE
- Current Assignee Address: US WA Seattle
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/68 ; C12Q1/37 ; A61K38/46 ; C12N15/10 ; A61K38/45 ; A61K38/52 ; C12N9/90 ; C12N15/62 ; C12N9/22 ; A61K9/00 ; A61K35/28 ; A61K35/12
Abstract:
The present disclosure relates to the co-expression of an endonuclease with an end-processing enzyme for the purpose of enhanced processing of the polynucleotide ends generated by endonuclease cleavage.
Public/Granted literature
- US20170152505A1 COUPLING ENDONUCLEASES WITH END-PROCESSING ENZYMES DRIVES HIGH EFFICIENCY GENE DISRUPTION Public/Granted day:2017-06-01
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