Systems and methods are provided for blade-and-slot panel affixation. One embodiment is a method. The method includes cutting a first slot into a first composite panel that includes a core between two facesheets. The first slot penetrates through the core of the first composite panel. The method also includes cutting a second slot into a second composite panel that includes a core between two facesheets. The second slot penetrates through a facesheet of the second composite panel as well as the core of the second composite panel. The method further includes inserting a blade into the first slot, and inserting the blade into the second slot.