Invention Grant
- Patent Title: Use of leucine-zipper protein for diagnosis or treatment of fatty liver
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Application No.: US16466698Application Date: 2017-11-20
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Publication No.: US10746727B2Publication Date: 2020-08-18
- Inventor: Jesang Ko , Min-Soo Kang
- Applicant: Korea University Research and Business Foundation
- Applicant Address: KR Seoul
- Assignee: Korea University Research and Business Foundation
- Current Assignee: Korea University Research and Business Foundation
- Current Assignee Address: KR Seoul
- Agency: Sughrue Mion, PLLC
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4cfa21e8
- International Application: PCT/KR2017/013154 WO 20171120
- International Announcement: WO2018/105921 WO 20180614
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07H21/04 ; G01N33/50 ; A61P1/16 ; C12N15/113 ; G01N33/68 ; A61K39/02
Abstract:
The present invention relates to a use of leucine-zipper protein for diagnosis or treatment of fatty liver. According to the present invention, it could be confirmed that a particular fragment present at the leucine-zipper protein, especially, the N-terminal region thereof, plays an important role in the lipid metabolism in liver tissue by regulating transcriptional activity of Apolipoprotein A4, and therefore, the protein of the present invention or a fragment thereof can be utilized as a target for diagnosis, prevention, or treatment of fatty liver.
Public/Granted literature
- US20190302101A1 USE OF LEUCINE-ZIPPER PROTEIN FOR DIAGNOSIS OR TREATMENT OF FATTY LIVER Public/Granted day:2019-10-03
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