Analyzing large datasets requires prioritization of analytical calculations to reduce analysis time and resource requirements. The prioritization process includes determining characteristics of a dataset, determining a list of analytical calculations, prioritizing the list of analytical calculations based on the dataset characteristics and characteristics of the analytical calculations, selecting the highest ranked analytical calculation, and applying the selected calculation on the dataset. The prioritization process of a new calculation based on a known set of calculations includes ranking the set of calculations based on their result scores from execution on a given dataset, comparing the new calculation to the list of known set of calculation, determining a similar calculation, and assigning the rank of the similar calculation to the new calculation.