A system and method for medical offices and other non-pharmacy providers using management systems or other billing systems based on the ASC X12 transaction standards to perform eligibility transactions, perform benefit predetermination transactions and to submit claims to pharmacy insurance companies or their pharmacy benefit managers that must receive the transactions as real-time transactions based on the NCPDP transaction standards are disclosed. Same medical offices and non-pharmacy providers can receive electronic remittance advice files from pharmacy insurance companies or their pharmacy benefit managers that contain data formatted and using identifiers that relate to the initial ASC X12 claims submitted.