Systems and methods are provided for enhanced real-time audio generation via a virtualized orchestra. An example method includes receiving, from a user device, a request to generate output associated with a musical score. Actions associated with virtual musicians with respect to respective instruments are simulated based on one or more machine learning models, with the simulated actions being associated with a virtual musician and indicative of an expected playing style during performance of the musical score. Output audio to be provided to the user device is generated, with the output audio being generated based on the simulated actions.