Systems and methods for facilitating communication with autonomous vehicles are provided. In one example embodiment, a computing system (e.g., of a vehicle) can generate a first communication associated with an autonomous vehicle. The computing system can provide the first communication to an application programming interface gateway that is remote from the autonomous vehicle. Another computing system can obtain, via an application programming interface gateway, the first communication associated with the autonomous vehicle. The other computing system can determine a first frontend interface of the application programming interface gateway based at least in part on the first communication associated with the autonomous vehicle. The computing system can provide, via the first frontend interface, the first communication associated with the autonomous vehicle to a first system client associated with the first frontend interface.