A method and system for proactively managing a base station neighbor list. A base station or other network node tracks changes to the base station's neighbor list and identifies a recurring pattern of changes, in correspondence with a particular time of day for instance. The base station or other node then proactively changes the base station's neighbor list in anticipation of a recurrence of the identified pattern, such as in anticipation of recurrence of the time of day for instance. Advantageously, this method can help to reduce the extent to which the base station engages in an automatic neighbor relation process, and thus reduce the extent of signaling and other issues associated with engaging in that process.