The present disclosure provides a method and a device in a User Equipment (UE) and a base station used for power saving. The UE first determines a first time-frequency resource set and K1 signature sequences, and then monitors the K1 signature sequences in the first time-frequency resource set; if any one of the K1 signature sequences is found in the first time-frequency resource set, the UE is woken up; the K1 signature sequences are used for generating K1 radio signals respectively; the first time-frequency resource set is one of K2 candidate time-frequency resource sets; and at least one of K1 and K2 is greater than 1. According to the present disclosure, the design of the K1 signature sequences effectively reduces the complexity of the UE detecting a wakeup signal, meanwhile, the number of UEs associated with one wakeup signal is flexibly configured.