A method generates an image sequence using a tomosynthesis system. The image sequence represents an object under examination in rotating fashion. In a first step at least two projection data sets for the object under examination are captured. These have been acquired using different X-ray spectra in each case and from a plurality of acquisition angles in each case. In a further step at least one combination data set is calculated on the basis of the projection data sets. Subsequently in a further step the image sequence is calculated on the basis of the combination data set. An image sequence generating apparatus and a tomosynthesis system perform this described method.