Introduced here are pressure-mitigation systems able to mitigate the pressure applied to a human body by a surface and associated methods for operating the same. A system can include a pressure-mitigation surface with a plurality of chambers whose pressure can be varied by a controller that regulates the flow of fluid produced by a pump. The plurality of chambers may be arranged in a geometric pattern designed to mitigate the pressure on a specific anatomic region when the human body is arranged over the pressure-mitigation surface.