Invention Grant
- Patent Title: Composition stably containing single-stranded nucleic acid molecule that suppresses expression of TGF-β1 gene
-
Application No.: US15771305Application Date: 2016-10-28
-
Publication No.: US10751426B2Publication Date: 2020-08-25
- Inventor: Taimu Yamada , Hidekazu Toyofuku , Kohei Tahara , Risako Onodera , Hirofumi Takeuchi
- Applicant: BONAC CORPORATION , Hirofumi Takeuchi
- Applicant Address: JP Kurume JP Gifu
- Assignee: BONAC CORPORATION,Hirofumi Takeuchi
- Current Assignee: BONAC CORPORATION,Hirofumi Takeuchi
- Current Assignee Address: JP Kurume JP Gifu
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@4b18ffdf
- International Application: PCT/JP2016/082164 WO 20161028
- International Announcement: WO2017/073767 WO 20170504
- Main IPC: A61K31/7105
- IPC: A61K31/7105 ; A61K31/7125 ; A61K47/02 ; A61K47/12 ; A61K47/16 ; A61K47/18 ; A61K47/26 ; A61P11/00 ; C07H21/02 ; C12N15/09 ; C12N15/10 ; C12N15/11 ; A61K48/00 ; C12N15/113 ; A61K9/08 ; C07H21/04

Abstract:
The present invention provides a composition containing a single-stranded nucleic acid molecule consisting of a nucleotide sequence shown by 5′-AGCAGAGUACACACAGCAUAUACC-P-GGUAUAUGCUGUGUGUACUCUGCUUC-P-G-3′ (SEQ ID NO: 1)(in the sequence, P is a proline derivative linker represented by (I) in the DESCRIPTION) and a buffer, and having the following features: (a) being in the form of a solution at ambient temperature; and (b) a content of the nucleic acid molecule after storage at 25° C., relative humidity 60% for 4 weeks, of not less than 80% relative to the content at the time of start of the storage.
Public/Granted literature
Information query
IPC分类: