A sliding distal component assembly for use in medical catheters, bioptomes and other medical devices is provided. The sliding distal component assembly includes a tubular shaft having a lumen, the tubular shaft coupled to an actuation mechanism moveable between a first position and a second position. A tip support is coupled to the tubular shaft and defines a tip support cavity therewithin. The sliding component assembly includes a pulley system having at least one pulley, a sliding distal component and at least one pull wire coupled to the pulley and the sliding distal component with at least a portion of said pulley system being housed within said tip support cavity. When the actuation mechanism is in the first position the sliding distal component is configured to translate proximally and when the actuation mechanism is in the second position the sliding distal component is configured to translate distally.