Embodiments of the present invention relate to apparatuses and methods for leakage detection for installed filters of a multi-filter containment enclosure, without requiring disassembly of the multi-filter containment enclosure. The containment enclosure of the present invention comprises a filter housing. The filter housing comprises one or more filter compartments for housing at least a first filter and a second filter. The filter housing comprises at least one port which is operatively coupled downstream of the first filter and upstream of the second filter. Typically, the at least one port allows for leak testing of the first filter and the second filter without having to remove the first filter and the second filter from the containment enclosure.