A response drone for detecting incidents within a coverage area including multiple zones is provided. With customer permission or affirmative consent, the drone may be programmed to (1) detect (or receive an indication of) triggering activity associated with one of the zones; (2) determine or receive a navigation path to that zone; (3) travel to that zone based upon the determined navigation path; (4) collect sensor data using drone-mounted sensors; and (5) transmit the collected sensor data to a user computing device associated with the coverage area for review. The response drone may be an autonomous drone in wireless communication with a smart home controller that detects triggering activity associated with an insurance-related event (e.g., fire). The autonomous drone may automatically deploy to mitigate damage to insured assets (e.g., a home or personal belongings). The autonomous drone data may be used for subsequent insurance claim handling and/or damage estimation.