Invention Grant
- Patent Title: Diamide macrocycles having factor XIa inhibiting activity
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Application No.: US16080418Application Date: 2017-03-01
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Publication No.: US10752641B2Publication Date: 2020-08-25
- Inventor: Jun Shi , William R. Ewing , Donald J. P. Pinto
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- International Application: PCT/US2017/020161 WO 20170301
- International Announcement: WO2017/151746 WO 20170908
- Main IPC: C07D498/10
- IPC: C07D498/10

Abstract:
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Public/Granted literature
- US20190062343A1 DIAMIDE MACROCYCLES HAVING FACTOR XIA INHIBITING ACTIVITY Public/Granted day:2019-02-28
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