Invention Grant
- Patent Title: Lentiviral vectors for regulated expression of a chimeric antigen receptor molecule
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Application No.: US15327517Application Date: 2015-07-24
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Publication No.: US10752668B2Publication Date: 2020-08-25
- Inventor: Sophie Agaugue , Lorenzo Tibaldi , Klervi Even-Desrumaux , Dmitry Trubetskoy , Franck Perez , Sebastian Amigorena , Cécile Bauche
- Applicant: THERAVECTYS , INSTITUT CURIE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE PIERRE ET MARIE CURIE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
- Applicant Address: FR Paris FR Paris FR Paris FR Paris FR Paris
- Assignee: Theravectys,Institut Curie,Centre National de la Recherche Scientifique,Sorbonne Universite,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee: Theravectys,Institut Curie,Centre National de la Recherche Scientifique,Sorbonne Universite,Institut National de la Sante et de la Recherche Medicale (INSERM)
- Current Assignee Address: FR Paris FR Paris FR Paris FR Paris FR Paris
- Agency: W&C IP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@34d35fc4
- International Application: PCT/EP2015/067090 WO 20150724
- International Announcement: WO2016/012623 WO 20160128
- Main IPC: C07K16/30
- IPC: C07K16/30 ; G01N33/574 ; C07K16/28 ; C07K14/705 ; C12N5/0783 ; A61K35/17 ; C07K16/00 ; A61K38/00

Abstract:
The invention relates to the regulated expression of a chimeric antigen receptor (CAR) within a lentiviral vector. The CAR comprises a hook-binding domain that interacts with a hook, preferably encoded by the same lentiviral vector, which prevents proper processing and release of the CAR to the cell membrane. The invention encompasses vectors, methods of making the vectors, and methods of using them, including medicinal uses. The vectors can be used for administration to humans to induce immune responses and to treat cancers and tumors.
Public/Granted literature
- US20170166623A1 LENTIVIRAL VECTORS FOR REGULATED EXPRESSION OF A CHIMERIC ANTIGEN RECEPTOR MOLECULE Public/Granted day:2017-06-15
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