Invention Grant
- Patent Title: Antigen-specific helper T-cell receptor genes
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Application No.: US14427465Application Date: 2013-09-12
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Publication No.: US10752669B2Publication Date: 2020-08-25
- Inventor: Haruo Sugiyama , Fumihiro Fujiki
- Applicant: International Institute of Cancer Immunology, Inc.
- Applicant Address: JP Osaka
- Assignee: International Institute of Cancer Immunology, Inc.
- Current Assignee: International Institute of Cancer Immunology, Inc.
- Current Assignee Address: JP Osaka
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@53cc2ede
- International Application: PCT/JP2013/074748 WO 20130912
- International Announcement: WO2014/042226 WO 20140320
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07K14/725 ; C12N5/0783 ; A61K35/17 ; C12Q1/6886 ; C07K16/28 ; C12Q1/6881 ; G01N33/569 ; A61K38/00
Abstract:
The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4+ helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4+ T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4+ T-cells, the treatment of cancer, etc.
Public/Granted literature
- US10815288B2 Antigen-specific helper T-cell receptor genes Public/Granted day:2020-10-27
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