Invention Grant
- Patent Title: DNA-binding domain of CRISPR system, non-fucosylated and partially fucosylated proteins, and methods thereof
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Application No.: US15526971Application Date: 2015-11-13
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Publication No.: US10752674B2Publication Date: 2020-08-25
- Inventor: Bhargav Prasad , Divya Unnikrishnan , Jahnabi Hazarika , Kavitha Iyer Rodrigues , Maloy Ghosh , Pavithra M , Pravin Kumar D , Sanghamitra Bhattacharjee , Sathyabalan M , Sankaranarayanan Srinivasan , Sohang Chatterjee , Sunit Maity , Veeresha K , Vivek Halan , Yogendra Manjunath B. M. , Anuradha Hora , Bairavabalakumar N , Karthika Nair , Aswini Thanigaivel , Amol Maliwalave , Bharath R Shenoy , Rajeshwari Pendse , Prabhat Kumar Pathak , Anisha Kurup , Sahana Bhima Rao
- Applicant: Zumutor Biologics, Inc.
- Applicant Address: US CA San Francisco
- Assignee: Zumutor Biologics Inc.
- Current Assignee: Zumutor Biologics Inc.
- Current Assignee Address: US CA San Francisco
- Agency: Fish & Richardson P.C.
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@22e6e49a
- International Application: PCT/IB2015/058777 WO 20151113
- International Announcement: WO2016/075662 WO 20160519
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C07K16/06 ; C12N15/113 ; C07K16/00 ; C12N5/07 ; C12N5/16 ; C12N15/10
Abstract:
The present disclosure relates to a method of obtaining a cell where fucosylation pathways are modified, leading to production of partially fucosylated and non-fucosylated protein products, specifically antibodies from the cell. The present disclosure employs the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) technology. The method of the present disclosure targets the Fut8 gene and GMD gene in a cell. Such products are used in developing therapeutics and biomarkers, and in diagnosis and prognosis of diseases.
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