- Patent Title: Variants of terminal deoxynucleotidyl transferase and uses thereof
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Application No.: US16423972Application Date: 2019-05-28
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Publication No.: US10752887B2Publication Date: 2020-08-25
- Inventor: Elise Champion , Mikhael Soskine , Thomas Ybert , Marc Delarue
- Applicant: DNA Script
- Applicant Address: FR Paris FR Paris
- Assignee: DNA Script,Institut Pasteur
- Current Assignee: DNA Script,Institut Pasteur
- Current Assignee Address: FR Paris FR Paris
- Agency: Bozicevic, Field & Francis LLP
- Agent Edward J. Baba
- Priority: com.zzzhc.datahub.patent.etl.us.BibliographicData$PriorityClaim@46396fbf
- Main IPC: C12P19/34
- IPC: C12P19/34 ; C12N9/12 ; C12N15/70
Abstract:
The present invention relates to variants of Terminal deoxynucleotidyl Transferase (TdT), each of which (i) has an amino acid sequence similarity to SEQ ID NO: 2. 11, 13, 15, 17, 19, 21, 23, 25, 27, 29, 31, 33 or 35 with corresponding amino acid substitutions, (ii) is capable of synthesizing a nucleic acid fragment without a template and (iii) is capable of incorporating a modified nucleotide into the nucleic acid fragment.
Public/Granted literature
- US20190390178A1 Variants of Terminal Deoxynucleotidyl Transferase and Uses Thereof Public/Granted day:2019-12-26
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