Invention Grant
- Patent Title: Compositions and methods for generating adeno-associated viral vectors with undetectable capsid gene contamination
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Application No.: US15073448Application Date: 2016-03-17
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Publication No.: US10752915B2Publication Date: 2020-08-25
- Inventor: Arthur Dusty Miller , Christine L. Halbert , Michael J. Metzger
- Applicant: Fred Hutchinson Cancer Research Center
- Applicant Address: US WA Seattle
- Assignee: Fred Hutchinson Cancer Research Center
- Current Assignee: Fred Hutchinson Cancer Research Center
- Current Assignee Address: US WA Seattle
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N15/86 ; C12N7/02
Abstract:
In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.
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