A data storage device includes a controller including a descriptor generation unit suitable for generating a descriptor and a memory controller suitable for generating a command based on the descriptor; and a nonvolatile memory device including a cell region, and suitable for reading first data from the cell region and buffering the first data in response to a first read command transmitted from the memory controller and outputting the first data to the controller in response to a first cache output command transmitted from the memory controller. The descriptor generation unit transmits an interrupt descriptor to the memory controller. The memory controller generates an interrupt to the descriptor generation unit based on the interrupt descriptor, and transmits the first cache output command to the nonvolatile memory device according to an instruction of the descriptor generation unit for the interrupt.