During an analysis technique, a three-dimensional (3D) image of a portion of an individual is iteratively transformed to facilitate accurate determination of detailed multi-point annotation of an anatomical structure. In particular, for a given marker point, in response to receiving information specifying a two-dimensional (2D) plane having an angular position in the 3D image, the 3D image is translated and rotated from an initial position and orientation so that the 2D plane is presented in an orientation parallel to a reference 2D plane of a display. Then, after annotation information specifying the detailed annotation in the 2D plane of the given marker point is received, the 3D image is translated and rotated back to the initial position and orientation. These operations may be repeated for one or more other marker points.