An imaging system, such as a DBT system, is provided that is capable of providing processing of an image from initial generation/reconstruction of the image through the review of the image by a radiologist or other practitioner that produces images optimized for the particular task/process performed using the images. The task/review that the radiologist is performing on the processed or reconstructed image can be modeled with regard to the initial generation of the processed or reconstructed images from the raw images or the model considerations can be retroactively applied and back propagated through the image processing performed by the system. These modeling considerations that can take the form of an indicator of clinical performance is/are used by the system to optimize and produce an image(s) that best represents the items in the image necessary for an accurate diagnosis of the patient when reviewed by the radiologist.