A home medication management system and method are provided comprise a home medication management device, a computing device associated with a user of medication management system, and a server in communication with the home medication management device and the computing device. The server comprises memory storing an application program interface (API) that is configured to manage the home medication of a patient including the registration of prescriptions, transmission of the registered prescriptions to the home medication management device, association of medications of the registered prescriptions with recesses of the home medication management device, presentation of alerts to the patient at scheduled times to take the medications based on the prescriptions, monitoring the patient for compliance with the alerts, determining whether the patient has taken the medication as scheduled, and presenting the determination to the user via the computing device.