The present disclosure provides RGB-LED packaging modules and a display screen including a substrate; a plurality of light-emitting units disposed on the substrate, each light-emitting unit including a set of RGB-LED chips; a plastic layer provided on the light-emitting units; and a virtual isolating region provided between the light-emitting units, the virtual isolating region including a black light-absorbing layer provided on the substrate. The present disclosure makes use of the black light-absorbing layer to absorb light which may cause interference among the light-emitting units. By providing the virtual isolating region and an isolating trough, and utilizing the difference of refractive index of packaging plastic and refractive index of air, light emitted by the light-emitting units can be reflected to reduce the influence of adjacent light-emitting units. A black isolating-frame is filled in the isolating trough to minimize the interference among the light-emitting units.