The systems and methods of the invention provide a notification system that analyzes the state of the user to deliver notifications when the user is anticipated to be both cognitively receptive AND able to act upon external stimuli. In accord with at least one aspect, the system assesses the context (of a user) by interpreting the user and surroundings in order to reach a general state of the user. In a technically efficient manner—utilizing different levels of processing in conjunction with leveraging previously performed processing through queuing results of such processing—the system provides the ability to reduce scenarios in which missed or inappropriate notifications occur. The systems and methods of the invention perform processing, in a technically efficient manner, to assess data input from sensors (in the real-world environment in which a user exists) and responsively generate appropriate notifications or other communications that are output to a user or a person associated with the user.