A smart folding box includes a support member, a number of folding members, a door, a locking mechanism, and a controller. The support member includes a support body and a connector. Each folding member is rotationally coupled to the support body and to the connector. The door is mounted on the connector and is configured to open or close an opening. The folding members are configured to fold or unfold to move the connector and the door. The locking mechanism includes an electric lock and a folding detection member. The electric lock and the folding detection member are electrically coupled to the controller and each mounted on one of the folding members. The support body defines a limiting slot. When the folding detection member detects that the folding members are in a folded state, the controller controls the electric lock to extend into the limiting slot.