A method, system, and computer program product are provided to automatically assess a plurality of fatigue mitigation strategies. In the context of a method, fatigue information is received for a subject and determination is made as to whether the subject is fatigued. In an instance in which the subject is fatigued, the method determines an estimated effectiveness of each of a plurality of fatigue mitigation strategies based upon fatigue information for the subject and one or more constraints and characteristics of a respective fatigue mitigation strategy. The determination of the estimated effectiveness of each of the plurality of fatigue mitigation strategies may also be based upon at least one of a time to become effective, a duration of the effectiveness and a side effect. The method also identifies at least one fatigue mitigation strategy to address fatigue of the subject.