A method and a corresponding system for assessing a haemodynamic parameter for a vascular region of interest of a patient based on angiographic images are provided. After acquiring multiple angiographic images, a three dimensional (3D) representation of at least a first portion of the respective region of interest is performed, and geometric features are extracted from complete or partial views. Additional geometric features are extracted from partial incomplete views. A complete set of 3D geometric features for an anatomical structure, such as a vessel tree, is then generated by combining the extracted geometric features and estimating any missing geometric features. Using the complete set of 3D geometric features, a feature-based assessment of the haemodynamic parameter, such as a fractional flow reserve, is then performed.