Skin treatment systems, handpieces, suction wands, and methods of treatment are disclosed herein. A skin treatment system includes a treatment handpiece with removable tips, a console unit, and a suction assembly. The console unit can have a pressurization device configured to be fluidically coupled to the suction assembly. The suction assembly is configured to hold a subject's skin while the treatment handpiece moves along the epidermis. The tips can replaced any number of times to perform during a treatment session.