Invention Grant
- Patent Title: Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxymorphone, prodrugs, methods of making and use thereof
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Application No.: US16573313Application Date: 2019-09-17
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Publication No.: US10758528B2Publication Date: 2020-09-01
- Inventor: Travis Mickle , Sven Guenther , Sanjib Bera , Jaroslaw Kanski , Andrea Martin
- Applicant: KemPharm, Inc.
- Applicant Address: US FL Celebration
- Assignee: KemPharm, Inc.
- Current Assignee: KemPharm, Inc.
- Current Assignee Address: US FL Celebration
- Agency: McAndrews, Held & Malloy, Ltd.
- Main IPC: C07D489/08
- IPC: C07D489/08 ; A61K31/485 ; A61K47/54 ; A61K47/55 ; C07D221/28
Abstract:
The presently described technology provides compositions comprising aryl carboxylic acids and, for example NSAIDs, chemically conjugated to oxymorphone (4,5-α-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxymorphone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxymorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
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