Invention Grant
- Patent Title: Respiratory syncytial virus having cleavage-resistant G protein and related materials and methods
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Application No.: US15737225Application Date: 2016-06-17
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Publication No.: US10758607B2Publication Date: 2020-09-01
- Inventor: Mark Edward Peeples , Steven A. Kwilas , Jacqueline Dianne Corry
- Applicant: The Research Institute at Nationwide Children's Hospital
- Applicant Address: US OH Columbus
- Assignee: The Research Institute at Nationwide Children's Hospital
- Current Assignee: The Research Institute at Nationwide Children's Hospital
- Current Assignee Address: US OH Columbus
- Agency: Faegre Drinker Biddle & Reath LLP
- International Application: PCT/US2016/038068 WO 20160617
- International Announcement: WO2016/205641 WO 20161222
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C07K14/005 ; A61K39/00

Abstract:
Embodiments disclosed herein provide compositions, methods, and uses for respiratory syncytial viruses (RSV) and immunogenic compositions thereof. Certain embodiments provide RSV having cleavage-resistant mutated attachment (G) glycoproteins. In some embodiments, the cleavage-resistant G protein mutants increase production of live attenuated RSV in host cells. Also provided are methods for amplifying RSV in host cells, wherein the amplified RSV has full length G protein. In certain embodiments, the amplified RSV having full length G protein is formulated into immunogenic compositions, including vaccines. Other embodiments provide methods for inducing an effective immune response against RSV infection in a subject.
Public/Granted literature
- US20190083600A1 RESPIRATORY SYNCYTIAL VIRUS HAVING CLEAVAGE-RESISTANT G PROTEIN AND RELATED MATERIALS AND METHODS Public/Granted day:2019-03-21
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