Invention Grant
- Patent Title: Conditioned surfaces for in situ molecular array synthesis
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Application No.: US15264426Application Date: 2016-09-13
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Publication No.: US10758886B2Publication Date: 2020-09-01
- Inventor: Neal Woodbury , Zhang-Gong Zhao
- Applicant: Arizona Board of Regents on behalf of Arizona State University
- Applicant Address: US AZ Scottsdale
- Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee: Arizona Board of Regents on behalf of Arizona State University
- Current Assignee Address: US AZ Scottsdale
- Agency: Byrne Poh LLP
- Agent Nina R. Horan
- Main IPC: B01J19/00
- IPC: B01J19/00 ; C07K1/04 ; C40B50/18 ; C40B80/00

Abstract:
Described herein are in situ synthesized arrays and methods of making them, wherein array signal sensitivity and robustness is enhanced by carrying out conditioning steps and/or generating linkers during synthesis. An array comprises a surface with a collection of features, wherein the features comprise molecules or polymers attached to the surface. In certain embodiments of the invention, carrying out conditioning steps during array synthesis can yield arrays with improved signal. In other embodiments, linkers are synthesized on the array surface prior to synthesis of functional molecules, wherein increasing linker length can correspond to an improvement in the signal generated by the array.
Public/Granted literature
- US20170106344A1 CONDITIONED SURFACES FOR IN SITU MOLECULAR ARRAY SYNTHESIS Public/Granted day:2017-04-20
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