Invention Grant
- Patent Title: Cu(I)-catalyzed azide-alkyne cycloadditions (CuAAC) ligands and methods for carrying out Cu(I)-catalyzed azide-alkyne cycloaddition reactions
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Application No.: US15515953Application Date: 2015-09-30
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Publication No.: US10758895B2Publication Date: 2020-09-01
- Inventor: Dexing Zeng
- Applicant: UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of The Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of The Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Clark Hill, PLC
- Agent Paul D. Bangor, Jr.
- International Application: PCT/US2015/053342 WO 20150930
- International Announcement: WO2016/054277 WO 20160407
- Main IPC: A61K9/00
- IPC: A61K9/00 ; B01J31/18 ; A61K49/00 ; A61K51/08 ; A61K51/10 ; B01D11/02 ; C07D249/04 ; G01N33/58
Abstract:
A Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core. A method for carrying out a Cu(I)-Catalyzed Azide-Alkyne Cycloaddition reaction, comprising: combining in a solution an alkyne-tagged component, an azide-tagged component and a Cu(I)-Catalyzed Azide-Alkyne Cycloadditions (CuAAC) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core; filtering the solution through a solid phase extraction filter to remove Cu(I)-ligand catalyst and/or excess ligand.
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