Invention Grant
- Patent Title: Aza-A-ring indenoisoquinoline topoisomerase I poisons
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Application No.: US16081959Application Date: 2017-03-15
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Publication No.: US10759795B2Publication Date: 2020-09-01
- Inventor: Mark S. Cushman , Daniel E. Beck , Yves Pommier
- Applicant: Purdue Research Foundation , National Institutes of Health
- Applicant Address: US IN West Lafayette US MD Bethesda
- Assignee: PURDUE RESEARCH FOUNDATION,UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: PURDUE RESEARCH FOUNDATION,UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US IN West Lafayette US MD Bethesda
- Agency: Brannon Sowers & Cracraft PC
- International Application: PCT/US2017/022389 WO 20170315
- International Announcement: WO2017/160898 WO 20170921
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/435
Abstract:
The invention described herein pertains to four series of aza-A-ring indenoisoquinolines, which are inhibitors of topoisomerase IB (Top1), and the processes for preparing said aza-A-ring indenoisoquinolines. Also described are methods for treating cancer in mammals using the described aza-A-ring indenoisoquinoline compounds or pharmaceutical formulations thereof.
Public/Granted literature
- US20190382401A1 AZA-A-RING INDENOISOQUINOLINE TOPOISOMERASE I POISONS Public/Granted day:2019-12-19
Information query
